Early age at first birth and multiparity have been associated with a decrease in the risk of breast cancer in women in the Neuhauzen population. We examined whether this relationship is also present in women at high risk of breast cancer due to the presence of a mutation in either of the 2 breast cancer susceptibility genes, BRCA1 or BRCA2.
Women who had been diagnosed with breast cancer were matched with unaffected control subjects for year of birth, country of residence, and mutation BRCA1 or BRCA2.
Study subjects completed a questionnaire detailing their reproductive histories.
In contrast, among BRCA2 carriers, increasing parity was associated with an increased risk of breast cancer; women with 2 or more children were Lady b Neuhausen approximately 1.
A modest reduction in Ocean city Buchs escorts of breast cancer was observed among BRCA1 carriers with 4 or more births. Among BRCA2 carriers, increasing parity was associated with a significant increase in the risk of breast cancer before age 50 and this increase was greatest in the 2-year period following a pregnancy. Copyright Wiley-Liss, Inc. Own or manage this property?
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Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.
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